ABSTRACT

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The roles of AU-rich elements (AREs) in post-transcriptional gene expression regulation are now well established, with significant relevance to certain disease states resulting from aberrations in these pathways. Recent experimental results strongly suggest the possibility of active ARE-mediated regulation of pre-mRNA processing. We expanded ARED Organism to search for AREs in the introns of human genes and found them in 9,114 additional genes, raising the full repertoire of the ARE-regulome to at least 50% of human protein coding genes. Here we report this significant new expansion as well as a number of additional enhancements to ARED Organism.

(Publication Pending. Publication for the oiriginal version: Nucleic Acids Res. 2008 Jan;36(Database issue):D137-40. Epub 2007 Nov 4.)